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The success or failure of clinical trials depends in large part on the level of PI engagement

Mentz and Petersen, Circulation: 2017; 1185-87.

PI-enroll®

Numerous software programs focus on site selection, protocol implementation and/or data management but only PI-enroll® addresses the ongoing decline in PI numbers and engagement stemming from Investigator "burnout" and "One-and-Done" experiences.

The approach PI-enroll takes is to save experienced PIs valuable time and effort, support and mentor less experienced investigators and generate a new population of clinical investigators.

Time-saving features include AI-driven summaries of each trial's need-to-know information accessible from a single page, eliminating the need to log into multiple portals; seamless toggling between competing trials; one-tap sharing of non-proprietary eligibility criteria with colleagues; and many more.

For early-career and new investigators, PI-Enroll highlights the personal and professional benefits of conducting clinical trials, offers guidance on trial procedures, GCP standards, and provides mentorship from the trial's more experienced investigators.

Save PIs and site teams time and effort
Increase investigator involvement and capacity
Increase patient enrollment and retention
Limit screen failures
Reduce protocol deviations
Improve data quality
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How PI-enroll® Helps to Ensure the Success of Clinical Trials

Designed by senior Principal Investigators, our platform maximizes PI involvement and streamlines clinical trial management.

Smart Pre-Screening

Select and prioritize trial criteria displayed on colleagues' mobile devices, thereby limiting inappropriate referrals and screen failures.

AI-Powered Protocol Summaries

Proprietary AI extracts and summarizes the need to know, practical information for each trial  eliminating the need to review extensive documentation.

Side-by-Side Trial Comparisons

Ensure the right patients are enrolled in the right trials by effortlessly  toggling back and forth between the same sections of competing trials.

Trial Awareness

Share non-proprietary, trial information with site and community-based colleagues to increase trial awareness and eligible patient referrals.

Improve Patient Retention

Enhanced  investigator/patient engagement and communication help maintain participant involvement throughout the entire  trial.

Immediate Implementation

Not considered a medical device and no patient identifiers - implementation can be immediate with no need for RB or IRB approvals.

Proven Results from Recent Phase 3 Trial

In a recent PI-Enroll supported trial, within 3-6 months of implementation:

+60%
PI Involvement
+110%
Patient Referrals
+80%
Patient Enrollment
90%
Rated PI-Enroll > 8/10
-50%
Patient Drop-outs
-20%
Protocol Deviations

Success Story: After implementing PI-enroll, one site that hadn't enrolled any patients for 12 months became the trial's leading enrollment site!

DNA

What Our Clients Say

Hear from  investigators and industry who have experienced the transformative power of our PI-Enroll platform.

"You guys have done it! You've discovered the 'Holy Grail' of clinical research"

Robert Mentz (PI)
Associate Professor of Medicine — Duke University, Durham, North Carolina USA

"I think this could be a game changer for clinical research sites."

Angie Schwab
Founder & CEO — EZ Research Solutions Inc.

"It's wonderful. I wish we had it for all our previous studies. We could have enrolled many more patients."

Yaacov Baruch (Sub-I)
Professor of Medicine — Ramban Hospital, Haifa, Israel

"….. great feedback from our investigators …."

Amy Olofson (SC)
Mayo Clinic Rochester, USA

"Finally, something that quickly tells me what I need to know without having to spend so much time navigating through a study center's web-site or Clinicaltrials.gov."

Marvin Slutchuk (HCP)
Miami, Florida, USA

"We're very excited about this (PI-Enroll) -- it should become standard operating practice for all clinical trials"

Jonathan M. Adams
Executive Vice-President — BioVie Inc.

"You have great technology and have gone above and beyond for customer service. It has all been greatly appreciated."

Jim Joffrion
Sr. Director, Clinical Development and Operations — Athersys Inc.

"I especially appreciate that it was developed by the very people that this tool is meant to serve, which would undoubtedly ensure its usefulness in solving some common challenges that both investigators and sponsors face."

Harlyn Silverstein
Scientific Advisor — GlaxoSmithKline

"Your App will spread through hospitals faster than COVID-19!"

Karen Doucette (PI)
Professor of Medicine, Consultant in Infectious Diseases — Edmonton, Canada

"How do we sign up?"

Geoffrey A Schick
Director, Strategic Site Partnerships — WCG Clinical Services

Our Flagship Product

PI-enroll® is Refuah Solution's lead and most successful product. This mobile platform employs proprietary, AI-based software to summarize the Need-To-Know information from clinical trial protocols and public sources.

Once summarized, checked for accuracy by Refuah physicians and approved by trial Sponsors, the selected trial information is added to a site's platform at no cost to sites.

Site-Specific Customization

PIs can render non-protocol fields site-specific to accommodate local patient populations and practice patterns.

Team Collaboration

PIs, Sub-Is, and Study Coordinators can share selected platform sections with site and community colleagues.

Multi-Site Communication

Sponsors and CROs can post messages and trial updates, providing additional communication beyond email.

EMRs, Electronic Medical Record system. Doctor using digital tablet recoding, analyzing digital patient's personal health history and information on digital document, global health technology

Addressing Industry Needs

Trial Success

Platform features designed to increase trial awareness,  patient referrals, enrollment and retention while limiting screen failures and protocol deviations.

Young Investigator Development

Dedicated section outlining  the benefits to being a clinical investigator, information about conducting clinical trials, and real-time mentorship from more senior investigators.

Same Day Integration

Trials can be onboarded onto the platform within 24 hours, eliminating  setup delays for upcoming trials  and facilitating rescue for
​slow-to-enroll ongoing trials.